Lyophilized platelets versus cryopreserved platelets for management of bleeding in thrombocytopenic dogs: A multicenter randomized clinical trial.

ABSTRACT:

Background

Thrombocytopenia in dogs is common in critical care medicine, but availability of fresh platelet concentrates in veterinary medicine can be limiting. Lyophilized platelets have long shelf-lives and can be easily transported, stored, and administered in various settings.

Objective

To evaluate the efficacy and safety of a novel trehalose-stabilized canine lyophilized platelet product in thrombocytopenic dogs with clinically-evident bleeding.

Animals

Eighty-eight dogs with platelet counts <50 × 10³ /μL and a standardized bleeding assessment tool (DOGiBAT) score ≥2.

Methods

Multicenter, randomized, non-blinded, non-inferiority clinical trial comparing dimethyl sulfoxide (DMSO)-stabilized cryopreserved platelet concentrates (CPP) with trehalose

SUBMITTER: Goggs R 

PROVIDER: S-EPMC7694820 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature