Effects of calcifediol supplementation on markers of chronic kidney disease-mineral and bone disorder in dogs with chronic kidney disease.

ABSTRACT:

Background

Chronic kidney disease-mineral and bone disorder (CKD-MBD) in dogs is associated with hypovitaminosis D, increased parathyroid hormone (PTH), and increased fibroblast growth factor-23 (FGF-23) concentrations. Best practice for vitamin D metabolite supplementation in CKD-MBD remains unknown.

Objective

To provide an extended-release calcifediol supplement to dogs with CKD and to measure its effects on variables indicative of CKD-MBD.

Animals

Ten dogs with International Renal Interest Society stages 2 and 3 CKD.

Methods

In a prospective study, dogs received a calcifediol supplement for 84 days. Serum 25-hydroxyvitamin D (25[OH]D), 1,25-dihydroxyvitamin D (1,25[OH]₂ D), 24,25-dihydroxyvitamin D (24,25[OH]₂ D), creatinine, calcium, p

SUBMITTER: Parker VJ 

PROVIDER: S-EPMC7694821 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature