Effect of oral administration of omeprazole on the microbiota of the gastric glandular mucosa and feces of healthy horses.

ABSTRACT:

Background

Omeprazole administration is associated with changes in gastric and fecal microbiota and increased incidence of Clostridioides difficile enterocolitis in humans and dogs.

Hypothesis/objectives

Study purpose was to assess the effect of omeprazole on gastric glandular and fecal microbiota in healthy adult horses.

Animals

Eight healthy horses stabled on straw and fed 100% haylage.

Methods

Prospective controlled study. Transendoscopic gastric glandular biopsies, gastric fluid, and fecal samples were obtained from each horse twice at a 7-day interval before the administration of omeprazole. Samples were taken on the same horses before and after a 7-day administration of omeprazole (4 mg/kg PO q24h). pH was assessed on fresh gastric fluid and other samples

SUBMITTER: Cerri S 

PROVIDER: S-EPMC7694827 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature