Prediction and measurement of diuretic responsiveness after oral administration of furosemide to healthy dogs and dogs with congestive heart failure.

ABSTRACT:

Background

In human patients, cumulative urine volume (uVol) and urine sodium (uNa) can be predicted using spot urine samples and these quantitative measures help detect low diuretic responsiveness (LDR).

Hypothesis/objectives

Formulas using spot urine samples predict cumulative uVol and uNa output after oral administration of furosemide to dogs.

Animals

Eight healthy dogs, 6 dogs with congestive heart failure (CHF).

Methods

Prospective interventional study. Spot urine samples at 180 and 270 minutes after furosemide (3 mg/kg PO) were used to predict cumulative uVol and uNa output over 7 hours. Differentiation of dogs fulfilling predefined criteria for LDR was examined using receiver operating characteristic (ROC) curves.

Results

Predicted uNa output at 1

SUBMITTER: Loughran KA 

PROVIDER: S-EPMC7694836 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature