Evaluation of changes in the epidemiology of leptospirosis in dogs after introduction of a quadrivalent antileptospiral vaccine in a highly endemic area.

ABSTRACT:

Background

Since 2003, a marked increase in leptospirosis serogroup Australis has been observed in dogs in Switzerland. In 2013, a new quadrivalent antileptospiral vaccine (L4) was introduced, adding serogroups Australis and Grippotyphosa to Canicola and Icterohaemorrhagiae of the previous bivalent vaccines (L2).

Objective

To examine whether introduction of L4 was associated with decreased incidence of leptospirosis and decreased odds for dogs with acute kidney injury (AKI) to be diagnosed with leptospirosis.

Animals

Four hundred and sixty-nine dogs with AKI presented to a referral hospital, including 269 dogs with leptospirosis and 200 controls with other causes.

Methods

Descriptive section: disease incidence was evaluated for 3 consecutive periods: before (PR

SUBMITTER: Francey T 

PROVIDER: S-EPMC7694862 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature