A serological framework to investigate acute primary and post-primary dengue cases reporting across the Philippines.

ABSTRACT:

Background

In dengue-endemic countries, targeting limited control interventions to populations at risk of severe disease could enable increased efficiency. Individuals who have had their first (primary) dengue infection are at risk of developing more severe secondary disease, thus could be targeted for disease prevention. Currently, there is no reliable algorithm for determining primary and post-primary (infection with more than one flavivirus) status from a single serum sample. In this study, we developed and validated an immune status algorithm using single acute serum samples from reporting patients and investigated dengue immuno-epidemiological patterns across the Philippines.

Methods

During 2015/2016, a cross-sectional sample of 10,137 dengue case reports provided serum

SUBMITTER: Biggs JR 

PROVIDER: S-EPMC7694902 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature