Insulin inhibits inflammation-induced cone death in retinal detachment.

ABSTRACT:

Background

Rhegmatogenous retinal detachment (RD) involving the macula is a major cause of visual impairment despite high surgical success rate, mainly because of cone death. RD causes the infiltration of activated immune cells, but it is not clear whether and how infiltrating inflammatory cells contribute to cone cell loss.

Methods

Vitreous samples from patients with RD and from control patients with macular hole were analyzed to characterize the inflammatory response to RD. A mouse model of RD and retinal explants culture were then used to explore the mechanisms leading to cone death.

Results

Analysis of vitreous samples confirms that RD induces a marked inflammatory response with increased cytokine and chemokine expression in humans, which is closely mimicked by ex

SUBMITTER: Conart JB 

PROVIDER: S-EPMC7694924 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature