Paxillin mediates ATP-induced activation of P2X7 receptor and NLRP3 inflammasome.

ABSTRACT:

Background

Extracellular adenosine triphosphate (ATP), a key danger-associated molecular pattern (DAMP) molecule, is released to the extracellular medium during inflammation by injured parenchymal cells, dying leukocytes, and activated platelets. ATP directly activates the plasma membrane channel P2X7 receptor (P2X7R), leading to an intracellular influx of K⁺, a key trigger inducing NLRP3 inflammasome activation. However, the mechanism underlying P2X7R-mediated activation of NLRP3 inflammasome is poorly understood, and additional molecular mediators have not been identified. Here, we demonstrate that Paxillin is the molecule connecting the P2X7 receptor and NLRP3 inflammasome through protein interactions.

Results

We show a distinct mechanism by which Paxillin prom

SUBMITTER: Wang W 

PROVIDER: S-EPMC7694937 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature