Immunological classification of gliomas based on immunogenomic profiling.

ABSTRACT:

Background

Gliomas are heterogeneous in the tumor immune microenvironment (TIM). However, a classification of gliomas based on immunogenomic profiling remains lacking.

Methods

We hierarchically clustered gliomas based on the enrichment levels of 28 immune cells in the TIM in five datasets and obtained three clusters: immunity-high, immunity-medium, and immunity-low.

Results

Glioblastomas were mainly distributed in immunity-high and immunity-medium, while lower-grade gliomas were distributed in all the three subtypes and predominated in immunity-low. Immunity-low displayed a better survival than other subtypes, indicating a negative correlation between immune infiltration and survival prognosis in gliomas. IDH mutations had a negative correlation with glioma immunity.

SUBMITTER: Feng Q 

PROVIDER: S-EPMC7694942 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature