Diversify and Conquer: The Vaccine Escapism of Plasmodium falciparum.

ABSTRACT: Over the last century, a great deal of effort and resources have been poured into the development of vaccines to protect against malaria, particularly targeting the most widely spread and deadly species of the human-infecting parasites: Plasmodium falciparum. Many of the known proteins the parasite uses to invade human cells have been tested as vaccine candidates. However, precisely because of the importance and immune visibility of these proteins, they tend to be very diverse, and in many cases redundant, which limits their efficacy in vaccine development. With the advent of genomics and constantly improving sequencing technologies, an increasingly clear picture is emerging of the vast genomic diversity of parasites from different geographic areas. This diversity is distributed throughout

SUBMITTER: Pance A 

PROVIDER: S-EPMC7694999 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature