TreeSAPP: the Tree-based Sensitive and Accurate Phylogenetic Profiler.

ABSTRACT:

Motivation

Microbial communities drive matter and energy transformations integral to global biogeochemical cycles, yet many taxonomic groups facilitating these processes remain poorly represented in biological sequence databases. Due to this missing information, taxonomic assignment of sequences from environmental genomes remains inaccurate.

Results

We present the Tree-based Sensitive and Accurate Phylogenetic Profiler (TreeSAPP) software for functionally and taxonomically classifying genes, reactions and pathways from genomes of cultivated and uncultivated microorganisms using reference packages representing coding sequences mediating multiple globally relevant biogeochemical cycles. TreeSAPP uses linear regression of evolutionary distance on taxonomic rank to improve class

SUBMITTER: Morgan-Lang C 

PROVIDER: S-EPMC7695126 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature