Nanotherapeutic Modulation of Human Neural Cells and Glioblastoma in Organoids and Monocultures.

ABSTRACT: Inflammatory processes in the brain are orchestrated by microglia and astrocytes in response to activators such as pathogen-associated molecular patterns, danger-associated molecular patterns and some nanostructures. Microglia are the primary immune responders in the brain and initiate responses amplified by astrocytes through intercellular signaling. Intercellular communication between neural cells can be studied in cerebral organoids, co-cultures or in vivo. We used human cerebral organoids and glioblastoma co-cultures to study glia modulation by dendritic polyglycerol sulfate (dPGS). dPGS is an extensively studied nanostructure with inherent anti-inflammatory properties. Under inflammatory conditions, lipocalin-2 levels in astrocytes are markedly increased and indirectly enhanced by sol

SUBMITTER: Zhang I 

PROVIDER: S-EPMC7695149 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature