Non-Coding RNAs as Sensors of Oxidative Stress in Neurodegenerative Diseases.

ABSTRACT: Oxidative stress (OS) results from an imbalance between the production of reactive oxygen species and the cellular antioxidant capacity. OS plays a central role in neurodegenerative diseases, where the progressive accumulation of reactive oxygen species induces mitochondrial dysfunction, protein aggregation and inflammation. Regulatory non-protein-coding RNAs (ncRNAs) are essential transcriptional and post-transcriptional gene expression controllers, showing a highly regulated expression in space (cell types), time (developmental and ageing processes) and response to specific stimuli. These dynamic changes shape signaling pathways that are critical for the developmental processes of the nervous system and brain cell homeostasis. Diverse classes of ncRNAs have been involved in the cell resp

SUBMITTER: Gamez-Valero A 

PROVIDER: S-EPMC7695195 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature