Development of Lidocaine-Loaded Dissolving Microneedle for Rapid and Efficient Local Anesthesia.

ABSTRACT: Lidocaine is a local anesthetic agent used in the form of injection and topical cream. However, these formulation types have limitations of being either painful or slow-acting, thereby hindering effective and complete clinical performance of lidocaine. Dissolving microneedles (DMNs) are used to overcome these limitations owing to their fast onset time and minimally invasive administration methods. Using hyaluronic acid and lidocaine to produce the drug solution, a lidocaine HCl encapsulated DMN (Li-DMN) was fabricated by centrifugal lithography. The drug delivery rate and local anesthetic quality of Li-DMNs were evaluated using the pig cadaver insertion test and Von Frey behavior test. Results showed that Li-DMNs could deliver sufficient lidocaine for anesthesia that is required to be util

SUBMITTER: Yang H 

PROVIDER: S-EPMC7695299 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature