CCL5-dependent mast cell infiltration into the tumor microenvironment in clear cell renal cell carcinoma patients.

ABSTRACT: We investigated the mechanisms affecting tumor progression and survival outcomes in Polybromo-1-mutated (PBRM1^MUT) clear cell renal cell carcinoma (ccRCC) patients. PBRM1^MUT ccRCC tissues contained higher numbers of mast cells and lower numbers of CD8⁺ and CD4⁺ T cells than tissues from PBRM1^WT ccRCC patients. Hierarchical clustering, pathway enrichment and GSEA analyses demonstrated that PBRM1 mutations promote tumor progression by activating hypoxia inducible factor (HIF)-related signaling pathways and increasing expression of vascular endothelial growth factor family genes. PBRM1^MUT ccRCC tissues also show increased expression of C-C motif chemokine ligand 5 (CCL5). PBRM1-silenced

SUBMITTER: Liu T 

PROVIDER: S-EPMC7695370 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature