Prognostic significance of survival-associated alternative splicing events in gastric cancer.

ABSTRACT: Alternative splicing events are a major source of transcript and protein diversity in eukaryotes. Aberrant alternative splicing events have been increasingly reported in various cancers, including gastric cancer. To further explore the prognostic significance of alternative splicing events in gastric cancer patients, a comprehensive and systematic investigation was conducted by integrating alternative splicing event data and clinical information. Univariate Cox regression analysis identified 1383 alternative splicing events to be significantly associated with the overall survival of gastric cancer patients. Then, least absolute shrinkage and selection operator (LASSO) and multivariate Cox analyses were performed for the development of prognostic signatures. The final prognostic signature b

SUBMITTER: Zhang S 

PROVIDER: S-EPMC7695385 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature