TCGA and ESTIMATE data mining to identify potential prognostic biomarkers in HCC patients.

ABSTRACT: Hepatocellular carcinoma (HCC) is an aggressive form of cancer characterized by a high recurrence rate following resection. Studies have implicated stromal and immune cells, which form part of the tumor microenvironment, as significant contributors to the poor prognoses of HCC patients. In the present study, we first downloaded gene expression datasets for HCC patients from The Cancer Genome Atlas database and categorized the patients into low and high stromal or immune score groups. By comparing those groups, we identified differentially expressed genes significantly associated with HCC prognosis. The Gene Ontology database was then used to perform functional enrichment analysis, and the STRING network database was used to construct protein-protein interaction networks. Our results show t

SUBMITTER: He G 

PROVIDER: S-EPMC7695391 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature