Multiple System Atrophy (MSA) and smoking: a meta-analysis and mechanistic insights.

ABSTRACT:

Background

The association between cigarette smoking and multiple system atrophy (MSA) has been debated. We conducted a systematic review and a meta-analysis to investigate this link.

Results

We identified 161 articles from database searching and bibliographic review. Five case-control studies satisfied the inclusion and exclusion criteria, and 435 and 352 healthy controls and MSA patients were examined. The prevalence of MSA amongst ever smokers was lower compared to never smokers (aOR=0.57; 95% CI, 0.29-1.14), although this result did not reach statistical significance. This was also observed for current and former smokers, with a stronger association for current smokers (aOR=0.63 vs aOR=0.96).

Conclusions

There is a suggestion that smoking protects against MSA. Pro

SUBMITTER: Tseng FS 

PROVIDER: S-EPMC7695394 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature