S-adenosylmethionine administration inhibits levodopa-induced vascular endothelial growth factor-A expression.

ABSTRACT:

Background

Studies have demonstrated that S-adenosylmethionine could effectively affect the clinical wearing-off phenomena of levodopa, an antiparkinsonian agent; however, the detailed mechanisms for this effect need to be further clarified.

Results

S-adenosylmethionine and levodopa had opposite effects on the protein stability of vascular endothelial growth factor-A. The analysis of tube formation and cell viability also showed the nonconforming functions of S-adenosylmethionine and levodopa on cell angiogenesis and proliferation. Meanwhile, S-adenosylmethionine could significantly abolish the increased angiogenesis and cell viability induced by levodopa. S-adenosylmethionine resulted in G1/S phase arrest, with decreased cyclin dependent kinase 4/6 and increased p16, a spec

SUBMITTER: Yan Y 

PROVIDER: S-EPMC7695432 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature