Retracing the evolutionary emergence of thymopoiesis.
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ABSTRACT:
SUBMITTER: Swann JB
PROVIDER: S-EPMC7695478 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Publications
Retracing the evolutionary emergence of thymopoiesis.
Swann Jeremy B JB Nusser Anja A Morimoto Ryo R Nagakubo Daisuke D Boehm Thomas T
Science advances 20201127 48
The onset of lymphocyte development in the vertebrate primordial thymus, about 500 million years ago, represents one of the foundational events of the emerging adaptive immune system. Here, we retrace the evolutionary trajectory of thymopoiesis, from early vertebrates to mammals, guided by members of the <i>Foxn1/4</i> transcription factor gene family, which direct the differentiation of the thymic microenvironment. Molecular engineering in transgenic mice recapitulated a gene duplication event, ...[more]
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