Persistent Activation of Innate Immunity in Patients with Primary Antibody Deficiencies.

ABSTRACT: Primary antibody deficiencies (PAD) represent a heterogeneous group of disorders, with common variable immunodeficiency being the most common with clinical significance. The main phenotypic defect resides in the inability of B cells to produce antibodies, and the cornerstone of therapy is immunoglobulin replacement treatment in order to fight infections. However, the management of the other inflammatory manifestations is inadequate, reinforcing the hypothesis that a complex genetic background affecting additional cell populations, such as polymorphonuclear cells (PMN) and monocytes, influences the expression of the clinical phenotype of the disease. In this study, we investigated by flow cytometry in different conditions (resting state, and after isolation and incubation, with and without

SUBMITTER: Tsinti G 

PROVIDER: S-EPMC7695510 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature