Effect of anticoagulants on fibrin clot structure: A comparison between vitamin K antagonists and factor Xa inhibitors.

ABSTRACT:

Background

Abnormal clot structure has been identified in patients with thrombotic disorders. Anticoagulant therapy offers clear benefits for thrombosis prevention and treatment by reducing blood clot formation and size; nevertheless, there are limited data on the effects of different anticoagulants, where clotting is initiated with different triggers, on clot structure.

Objectives

Our aim was to investigate the effects of vitamin K antagonists and factor Xa inhibitors on clot structure.

Methods

Clots from pooled plasma spiked with rivaroxaban, apixaban, or enoxaparin, as well as plasma from patients on warfarin, were compared to plasma without anticoagulation. The kinetic profile of polymerizing clots was obtained by turbidity, fiber density was determined by confoca

SUBMITTER: Gauer JS 

PROVIDER: S-EPMC7695561 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature