Rapid induction of gliogenesis in OLIG2 and NKX2.2-expressing progenitors-derived spheroids.

ABSTRACT: Glial cells are crucial for the development of the central nervous system and the maintenance of chemical homeostasis. The process of gliogenesis has been well studied in the rodent brain, but it remains less well studied in the human brain. In addition, rodent glial cells differ from human counterparts in terms of morphologies, functions, and anatomical locations. Cerebral organoids (also referred to as spheroids) derived from human pluripotent stem cells (hPSCs) have been developed and are suitable cell-based models for researching developmental and neurodegenerative diseases. The in vitro generation of glia, including astrocytes and oligodendrocytes, from such organoids represents a promising tool to model neuronal diseases. Here, we showed that three-dimensional (3D) culture of OLIG2-

SUBMITTER: Yun W 

PROVIDER: S-EPMC7695630 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature