The leading edge: Emerging neuroprotective and neuroregenerative cell-based therapies for spinal cord injury.

ABSTRACT: Spinal cord injuries (SCIs) are associated with tremendous physical, social, and financial costs for millions of individuals and families worldwide. Rapid delivery of specialized medical and surgical care has reduced mortality; however, long-term functional recovery remains limited. Cell-based therapies represent an exciting neuroprotective and neuroregenerative strategy for SCI. This article summarizes the most promising preclinical and clinical cell approaches to date including transplantation of mesenchymal stem cells, neural stem cells, oligodendrocyte progenitor cells, Schwann cells, and olfactory ensheathing cells, as well as strategies to activate endogenous multipotent cell pools. Throughout, we emphasize the fundamental biology of cell-based therapies, critical features in the pat

SUBMITTER: Ahuja CS 

PROVIDER: S-EPMC7695641 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature