In vitro investigation of chemical properties and biocompatibility of neurovascular braided implants.

ABSTRACT: Braiding of Nitinol micro wires is an established technology for the manufacturing of fine-meshed neurovascular implants for tortuous vessel geometries. Electropolishing of wires before the braiding process has the potential to improve the in vitro behaviour in terms of thrombogenicity and endothelial cell proliferation. In this study, we present the first in vitro investigation of braided electropolished/blue oxide Nitinol samples in a blood flow loop, showing a significantly lower activation of the coagulation pathway (represented by the TAT III marker) and a tendency towards reduced platelet adhesion. Furthermore, we applied the same surface treatment on flat disks and measured protein adhesion as well as endothelial cell proliferation. We compared our results to non-electropolished sam

SUBMITTER: Cattaneo G 

PROVIDER: S-EPMC7695648 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature