Effects of Therapies on Cardiovascular Events in Ankylosing Spondylitis: A Systematic Review and Meta-Analysis.

ABSTRACT:

Introduction

Non-steroidal anti-inflammatory drugs (NSAIDs) and tumor necrosis factor inhibitors (TNFi) are the most common therapies used in AS, however, the associated long-term cardiovascular risk is unclear. We performed a systematic review and meta-analysis on the association of therapies used for ankylosing spondylitis (AS) such as NSAIDs and TNFi on cardiovascular events (CVE) in AS.

Methods

A comprehensive search was performed from database inception to May 29, 2020 to include controlled studies of AS treated with NSAIDs, oral small molecules, or biologics reporting CVE. Study-specific risk ratios (RR) were pooled using a random effects model.

Results

Nine non-randomized studies from 1570 studies screened fulfilled inclusion criteria. Among NSAID users as a wh

SUBMITTER: Karmacharya P 

PROVIDER: S-EPMC7695658 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature