Tumor Microenvironment and Immunotherapy Response in Head and Neck Cancer.

ABSTRACT: The tumor microenvironment (TME) encompasses cellular and non-cellular components which play an important role in tumor evolution, invasion, and metastasis. A complicated interplay between tumor cells and adjacent TME cells, such as stromal cells, immune cells, inflammatory cells, and cytokines, leads to severe immunosuppression and the proliferation of cancer cells in several solid tumors. An immunosuppressive TME has a significant impact on treatment resistance and may guide response to immunotherapy. In head and neck cancer (HNC), immunotherapeutic drugs have been incorporated in everyday clinical practice. However, despite an exceptional rate of durable responses, only a low percentage of patients respond. In this review, we will focus on the complex interactions occurring in this dyna

SUBMITTER: Economopoulou P 

PROVIDER: S-EPMC7696050 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature