Recurrence Risk after Radical Colorectal Cancer Surgery-Less Than before, But How High Is It?

ABSTRACT: Adjuvant chemotherapy aims at eradicating tumour cells sometimes present after radical surgery for a colorectal cancer (CRC) and thereby diminish the recurrence rate and prolong time to recurrence (TTR). Remaining tumour cells will lead to recurrent disease that is usually fatal. Adjuvant therapy is administered based upon the estimated recurrence risk, which in turn defines the need for this treatment. This systematic overview aims at describing whether the need has decreased since trials showing that adjuvant chemotherapy provides benefits in colon cancer were performed decades ago. Thanks to other improvements than the administration of adjuvant chemotherapy, such as better staging, improved surgery, the use of radiotherapy and more careful pathology, recurrence risks have decreased. Me

SUBMITTER: Osterman E 

PROVIDER: S-EPMC7696064 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature