Autophagy Stimulus-Dependent Role of the Small GTPase Ras2 in Peroxisome Degradation.

ABSTRACT: The changing accessibility of nutrient resources induces the reprogramming of cellular metabolism in order to adapt the cell to the altered growth conditions. The nutrient-depending signaling depends on the kinases mTOR (mechanistic target of rapamycin), which is mainly activated by nitrogen-resources, and PKA (protein kinase A), which is mainly activated by glucose, as well as both of their associated factors. These systems promote protein synthesis and cell proliferation, while they inhibit degradation of cellular content by unselective bulk autophagy. Much less is known about their role in selective autophagy pathways, which have a more regulated cellular function. Especially, we were interested to analyse the central Ras2-module of the PKA-pathway in the context of peroxisome degradati

SUBMITTER: Boutouja F 

PROVIDER: S-EPMC7696409 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature