Interactions between Candida albicans and Enterococcus faecalis in an Organotypic Oral Epithelial Model.

ABSTRACT: Candida albicans as an opportunistic pathogen exploits the host immune system and causes a variety of life-threatening infections. The polymorphic nature of this fungus gives it tremendous advantage to breach mucosal barriers and cause oral and disseminated infections. Similar to C. albicans, Enterococcus faecalis is a major opportunistic pathogen, which is of critical concern in immunocompromised patients. There is increasing evidence that E. faecalis co-exists with C. albicans in the human body in disease samples. While the interactive profiles between these two organisms have been studied on abiotic substrates and mouse models, studies on their interactions on human oral mucosal surfaces are non-existent. Here, for the first time, we comprehensively ch

SUBMITTER: Krishnamoorthy AL 

PROVIDER: S-EPMC7696566 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature