Mechano-activated biomolecule release in regenerating load-bearing tissue microenvironments.

ABSTRACT: Although mechanical loads are integral for musculoskeletal tissue homeostasis, overloading and traumatic events can result in tissue injury. Conventional drug delivery approaches for musculoskeletal tissue repair employ localized drug injections. However, rapid drug clearance and inadequate synchronization of molecule provision with healing progression render these methods ineffective. To overcome this, a programmable mechanoresponsive drug delivery system was developed that utilizes the mechanical environment of the tissue during rehabilitation (for example, during cartilage repair) to trigger biomolecule provision. For this, a suite of mechanically-activated microcapsules (MAMCs) with different rupture profiles was generated in a single fabrication batch via osmotic annealing of double e

SUBMITTER: Peredo AP 

PROVIDER: S-EPMC7696653 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature