In Silico Identification of SOX1 Post-Translational Modifications Highlights a Shared Protein Motif.

ABSTRACT: The transcription factor SOX1 is a key regulator of neural stem cell development, acting to keep neural stem cells (NSCs) in an undifferentiated state. Postnatal expression of Sox1 is typically confined to the central nervous system (CNS), however, its expression in non-neural tissues has recently been implicated in tumorigenesis. The mechanism through which SOX1 may exert its function is not fully understood, and studies have mainly focused on changes in SOX1 expression at a transcriptional level, while its post-translational regulation remains undetermined. To investigate this, data were extracted from different publicly available databases and analysed to search for putative SOX1 post-translational modifications (PTMs). Results were compared to PTMs associated with SOX2 in order to iden

SUBMITTER: Ahmad A 

PROVIDER: S-EPMC7696889 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature