Emerging BRAF Mutations in Cancer Progression and Their Possible Effects on Transcriptional Networks.

ABSTRACT: Gene mutations can induce cellular alteration and malignant transformation. Development of many types of cancer is associated with mutations in the B-raf proto-oncogene (BRAF) gene. The encoded protein is a component of the mitogen-activated protein kinases/extracellular signal-regulated kinases (MAPK/ERK) signaling pathway, transmitting information from the outside to the cell nucleus. The main function of the MAPK/ERK pathway is to regulate cell growth, migration, and proliferation. The most common mutations in the BRAF gene encode the V600E mutant (class I), which causes continuous activation and signal transduction, regardless of external stimulus. Consequently, cell proliferation and invasion are enhanced in cancer patients with such mutations. The V600E mutation has been linked to me

SUBMITTER: Smiech M 

PROVIDER: S-EPMC7697059 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature