Gene Expression Profiling in Huntington's Disease: Does Comorbidity with Depressive Symptoms Matter?

ABSTRACT: Huntington's disease (HD) is an inherited neurodegenerative disease. Besides the well-characterized motor symptoms, HD is marked by cognitive impairment and behavioral changes. In this study, we analyzed the blood of HD gene carries using RNA-sequencing techniques. We evaluated samples from HD gene carriers with (n = 8) and without clinically meaningful depressive symptoms (n = 8) compared with healthy controls (n = 8). Groups were age- and sex-matched. Preprocessing of data and between-group comparisons were calculated using DESeq2. The Wald test was used to generate p-values and log2 fold changes. We found 60 genes differently expressed in HD and healthy controls, of which 21 were upregulated and 39 downregulated. Within HD group, nineteen genes were differently expressed between patient

SUBMITTER: Colpo GD 

PROVIDER: S-EPMC7697115 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature