Moderate, but Not Excessive, Training Attenuates Autophagy Machinery in Metabolic Tissues.

ABSTRACT: The protective effects of chronic moderate exercise-mediated autophagy include the prevention and treatment of several diseases and the extension of lifespan. In addition, physical exercise may impair cellular structures, requiring the action of the autophagy mechanism for clearance and renovation of damaged cellular components. For the first time, we investigated the adaptations on basal autophagy flux in vivo in mice's liver, heart, and skeletal muscle tissues submitted to four different chronic exercise models: endurance, resistance, concurrent, and overtraining. Measuring the autophagy flux in vivo is crucial to access the functionality of the autophagy pathway since changes in this pathway can occur in more than five steps. Moreover, the responses of metabolic, performance, and functi

SUBMITTER: da Rocha AL 

PROVIDER: S-EPMC7697344 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature