The Expression Profiles of ADME Genes in Human Cancers and Their Associations with Clinical Outcomes.

ABSTRACT: ADME genes are a group of genes that are involved in drug absorption, distribution, metabolism, and excretion (ADME). The expression profiles of ADME genes within tumours is proposed to impact on cancer patient survival; however, this has not been systematically examined. In this study, our comprehensive analyses of pan-cancer datasets from the Cancer Genome Atlas (TCGA) revealed differential intratumoral expression profiles for ADME genes in 21 different cancer types. Most genes also showed high interindividual variability within cancer-specific patient cohorts. Using Kaplan-Meier plots and logrank tests, we showed that intratumoral expression levels of twenty of the thirty-two core ADME genes were associated with overall survival (OS) in these cancers. Of these genes, five showed signifi

SUBMITTER: Hu DG 

PROVIDER: S-EPMC7697355 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature