NLRP3 Inflammasome Activation Is Involved in LPA₁-Mediated Brain Injury after Transient Focal Cerebral Ischemia.

ABSTRACT: Lysophosphatidic acid receptor 1 (LPA₁) contributes to brain injury following transient focal cerebral ischemia. However, the mechanism remains unclear. Here, we investigated whether nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3 (NLRP3) inflammasome activation might be an underlying mechanism involved in the pathogenesis of brain injury associated with LPA₁ following ischemic challenge with transient middle cerebral artery occlusion (tMCAO). Suppressing LPA₁ activity by its antagonist attenuated NLRP3 upregulation in the penumbra and ischemic core regions, particularly in ionized calcium-binding adapter molecule 1 (Iba1)-expressing cells like macrophages of mouse after tMCAO challenge. It also suppressed NLRP3 infl

SUBMITTER: Lee CH 

PROVIDER: S-EPMC7697439 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature