Unknown

Dataset Information

0

BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives.

ABSTRACT: A strong association between pancreatic cancer and BRCA1 and BRCA2 mutations is documented. Based on promising results of breast and ovarian cancers, several clinical trials with poly (ADP-ribose) polymerase inhibitors (PARPi) are ongoing for gastrointestinal (GI) malignancies, especially for pancreatic cancer. Indeed, the POLO trial results provide promising and awaited changes for the pancreatic cancer therapeutic landscape. Contrariwise, for other gastrointestinal tumors, the rationale is currently only alleged. The role of BRCA mutation in gastrointestinal cancers is the subject of this review. In particular, we aim to provide the latest updates about novel therapeutic strategies that, exploiting DNA repair defects, promise to shape the future therapeutic scenario of GI cancers.

SUBMITTER: Molinaro E 

PROVIDER: S-EPMC7697442 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

BRCA in Gastrointestinal Cancers: Current Treatments and Future Perspectives.

Molinaro Eleonora E   Andrikou Kalliopi K   Casadei-Gardini Andrea A   Rovesti Giulia G  

Cancers 20201112 11

A strong association between pancreatic cancer and <i>BRCA1</i> and <i>BRCA2</i> mutations is documented. Based on promising results of breast and ovarian cancers, several clinical trials with poly (ADP-ribose) polymerase inhibitors (PARPi) are ongoing for gastrointestinal (GI) malignancies, especially for pancreatic cancer. Indeed, the POLO trial results provide promising and awaited changes for the pancreatic cancer therapeutic landscape. Contrariwise, for other gastrointestinal tumors, the ra  ...[more]

Similar Datasets

Unknown Current and Future Immunotherapy-Based Treatments for Oesophageal Cancers.
| S-EPMC9265112 | biostudies-literature
Transcriptomics Transcriptional profiling of microglia; current state of the art and future perspectives
2019-08-10 | GSE135618 | GEO
Unknown Upper gastrointestinal malignancies in 2017: current perspectives and future approaches.
| S-EPMC5925434 | biostudies-literature
Unknown Current Status and Future Perspective of Immunotherapy in Gastrointestinal Cancers.
| S-EPMC8454608 | biostudies-literature
Unknown Role of Circulating Tumor DNA in Gastrointestinal Cancers: Current Knowledge and Perspectives
| S-EPMC8507552 | biostudies-literature
Unknown Emerging Role of C5 Complement Pathway in Peripheral Neuropathies: Current Treatments and Future Perspectives.
| S-EPMC8067968 | biostudies-literature
Unknown Trimodality treatment in gastric and gastroesophageal junction cancers: Current approach and future perspectives
| S-EPMC8790425 | biostudies-literature
Unknown Future perspectives: Moving towards NCL treatments.
| S-EPMC4567439 | biostudies-literature
Unknown BRCA mutations and gastrointestinal cancers: When to expect the unexpected?
| S-EPMC8317649 | biostudies-literature
Unknown Food Allergies: Current and Future Treatments.
| S-EPMC6571952 | biostudies-literature