Ontology highlight
ABSTRACT:
SUBMITTER: Diene SM
PROVIDER: S-EPMC7697635 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Diene Seydina M SM Pinault Lucile L Armstrong Nicholas N Azza Said S Keshri Vivek V Khelaifia Saber S Chabrière Eric E Caetano-Anolles Gustavo G Rolain Jean-Marc JM Pontarotti Pierre P Raoult Didier D
Life (Basel, Switzerland) 20201114 11
β-lactam antibiotics have a well-known activity which disturbs the bacterial cell wall biosynthesis and may be cleaved by β-lactamases. However, these drugs are not active on archaea microorganisms, which are naturally resistant because of the lack of β-lactam target in their cell wall. Here, we describe that annotation of genes as β-lactamases in Archaea on the basis of homologous genes is a remnant of identification of the original activities of this group of enzymes, which in fact have multip ...[more]