Metabolic Alterations Caused by Defective Cardiolipin Remodeling in Inherited Cardiomyopathies.

ABSTRACT: The heart is the most energy-consuming organ in the human body. In heart failure, the homeostasis of energy supply and demand is endangered by an increase in cardiomyocyte workload, or by an insufficiency in energy-providing processes. Energy metabolism is directly associated with mitochondrial redox homeostasis. The production of toxic reactive oxygen species (ROS) may overwhelm mitochondrial and cellular ROS defense mechanisms in case of heart failure. Mitochondria are essential cell organelles and provide 95% of the required energy in the heart. Metabolic remodeling, changes in mitochondrial structure or function, and alterations in mitochondrial calcium signaling diminish mitochondrial energy provision in many forms of cardiomyopathy. The mitochondrial respiratory chain creates a proto

SUBMITTER: Wasmus C 

PROVIDER: S-EPMC7697959 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature