Dimeric and Multimeric DNA Aptamers for Highly Effective Protein Recognition.

ABSTRACT: Multivalent interactions frequently occur in biological systems and typically provide higher binding affinity and selectivity in target recognition than when only monovalent interactions are operative. Thus, taking inspiration by nature, bivalent or multivalent nucleic acid aptamers recognizing a specific biological target have been extensively studied in the last decades. Indeed, oligonucleotide-based aptamers are suitable building blocks for the development of highly efficient multivalent systems since they can be easily modified and assembled exploiting proper connecting linkers of different nature. Thus, substantial research efforts have been put in the construction of dimeric/multimeric versions of effective aptamers with various degrees of success in target binding affinity or therap

SUBMITTER: Riccardi C 

PROVIDER: S-EPMC7698228 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature