Proteomic Insights into Senescence of Testicular Peritubular Cells from a Nonhuman Primate Model.

ABSTRACT: Age-related changes in the human testis may include morphological alterations, disturbed steroidogenesis, and impaired spermatogenesis. However, the specific impact of cell age remains poorly understood and difficult to assess. Testicular peritubular cells fulfill essential functions, including sperm transport, contributions to the spermatogonial stem cell niche, and paracrine interactions within the testis. To study their role in age-associated decline of testicular functions, we performed comprehensive proteome and secretome analyses of repeatedly passaged peritubular cells from Callithrix jacchus. This nonhuman primate model better reflects the human testicular biology than rodents and further gives access to young donors unavailable from humans. Among 5095 identified proteins, 5

SUBMITTER: Stockl JB 

PROVIDER: S-EPMC7698562 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature