Candidate Gene Markers Associated with Fecal Shedding of the Feline Enteric Coronavirus (FECV).

ABSTRACT: The Feline coronavirus (FCoV) can cause a fatal disease, the Feline Infectious Peritonitis. Persistent shedders represent the most important source of infection. The role of the host in FCoV fecal shedding is unknown. The objective of this study was to develop gene markers and to test their associations with FCoV shedding patterns. Fecal samples were taken from 57 cats of 12 breeds on the day 0 and after 2, 4 and 12 months. Variation from persistent and/or high-intensity shedding to no shedding was observed. Thirteen immunity-related genes were selected as functional and positional/functional candidates. Positional candidates were selected in a candidate region detected by a GWAS analysis. Tens to hundreds of single nucleotide polymorphisms (SNPs) per gene were identified using next genera

SUBMITTER: Bubenikova J 

PROVIDER: S-EPMC7698596 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature