Evolution and genetic diversity of SARS-CoV-2 in Africa using whole genome sequences.

ABSTRACT:

Background

The ongoing SARS-CoV-2 pandemic was introduced into Africa on 14th February 2020 and has rapidly spread across the continent causing a severe public health crisis and mortality. We investigated the genetic diversity and evolution of this virus during the early outbreak months, between 14th February to 24th April 2020, using whole genome sequences.

Methods

We performed recombination analysis against closely related CoV strains, Bayesian time scaled phylogeny, and investigation of spike protein amino acid mutations.

Results

Recombination signals were observed between the Afr-SARS-CoV-2 sequences and reference sequences within the RdRPs and S genes. The evolutionary rate of the Afr-SARS-CoV-2 was 4.133 × 10^-4 Highest Posterior Density (HPD 4.132 × 1

SUBMITTER: Motayo BO 

PROVIDER: S-EPMC7698667 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature