Quantitative Imaging Parameters of Contrast-Enhanced Micro-Computed Tomography Correlate with Angiogenesis and Necrosis in a Subcutaneous C6 Glioma Model.

ABSTRACT: The aim of this work was to systematically obtain quantitative imaging parameters with static and dynamic contrast-enhanced (CE) X-ray imaging techniques and to evaluate their correlation with histological biomarkers of angiogenesis in a subcutaneous C6 glioma model. Enhancement (E), iodine concentration (C_I), and relative blood volume (rBV) were quantified from single- and dual-energy (SE and DE, respectively) micro-computed tomography (micro-CT) images, while rBV and volume transfer constant (K^trans) were quantified from dynamic contrast-enhanced (DCE) planar images. C_I and rBV allowed a better discernment of tumor regions from muscle than E in SE and DE images, while no significant differences were found for rBV and K^trans in DCE images. An ag

SUBMITTER: Ayala-Dominguez L 

PROVIDER: S-EPMC7698719 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature