Impaired Expression of GABA Signaling Components in the Alzheimer's Disease Middle Temporal Gyrus.

ABSTRACT: γ-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter, playing a central role in the regulation of cortical excitability and the maintenance of the excitatory/inhibitory (E/I) balance. Several lines of evidence point to a remodeling of the cerebral GABAergic system in Alzheimer's disease (AD), with past studies demonstrating alterations in GABA receptor and transporter expression, GABA synthesizing enzyme activity and focal GABA concentrations in post-mortem tissue. AD is a chronic neurodegenerative disorder with a poorly understood etiology and the temporal cortex is one of the earliest regions in the brain to be affected by AD neurodegeneration. Utilizing NanoString nCounter analysis, we demonstrate here the transcriptional downregulation of several GABA signaling compone

SUBMITTER: Govindpani K 

PROVIDER: S-EPMC7698927 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature