Absence of mgrB Alleviates Negative Growth Effects of Colistin Resistance in Enterobacter cloacae.

ABSTRACT: Colistin is an important last-line antibiotic to treat highly resistant Enterobacter infections. Resistance to colistin has emerged among clinical isolates but has been associated with a significant growth defect. Here, we describe a clinical Enterobacter isolate with a deletion of mgrB, a regulator of colistin resistance, leading to high-level resistance in the absence of a growth defect. The identification of a path to resistance unrestrained by growth defects suggests colistin resistance could become more common in Enterobacter.

SUBMITTER: Wozniak JE 

PROVIDER: S-EPMC7699182 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature