Bioinformatics identification and pharmacological validation of Kcnn3/K_Ca2 channels as a mediator of negative affective behaviors and excessive alcohol drinking in mice.

ABSTRACT: Mood disorders are often comorbid with alcohol use disorder (AUD) and play a considerable role in the development and maintenance of alcohol dependence and relapse. Because of this high comorbidity, it is necessary to determine shared and unique genetic factors driving heavy drinking and negative affective behaviors. In order to identify novel pharmacogenetic targets, a bioinformatics analysis was used to quantify the expression of amygdala K⁺ channel genes that covary with anxiety-related phenotypes in the well-phenotyped and fully sequenced family of BXD strains. We used a model of stress-induced escalation of drinking in alcohol-dependent mice to measure negative affective behaviors during abstinence. A pharmacological approach was used to validate the key bioinformatics find

SUBMITTER: Padula AE 

PROVIDER: S-EPMC7699620 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature