Process Design of Continuous Powder Blending Using Residence Time Distribution and Feeding Models.

ABSTRACT: The present paper reports a thorough continuous powder blending process design of acetylsalicylic acid (ASA) and microcrystalline cellulose (MCC) based on the Process Analytical Technology (PAT) guideline. A NIR-based method was applied using multivariate data analysis to achieve in-line process monitoring. The process dynamics were described with residence time distribution (RTD) models to achieve deep process understanding. The RTD was determined using the active pharmaceutical ingredient (API) as a tracer with multiple designs of experiment (DoE) studies to determine the effect of critical process parameters (CPPs) on the process dynamics. To achieve quality control through material diversion from feeding data, soft sensor-based process control tools were designed using the RTD model. T

SUBMITTER: Gyurkes M 

PROVIDER: S-EPMC7699818 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature