Population Difference in Allele Frequency of HLA-C*05 and Its Correlation with COVID-19 Mortality.

ABSTRACT: coronavirus disease 2019 (COVID-19) causes severe illness including cytokine storms, but mortality among countries differs largely. In the present study, we investigated the association between human leukocyte antigen (HLA) class I, which plays a major role in susceptibility to viral infections, and the mortality of COVID-19. data of allele frequencies of HLA-A, -B and -C and COVID-19 mortality were obtained for 74 countries from the Allele Frequency Net Database and worldometer.info. Association between allele frequency of each HLA and mortality was assessed by linear regression followed by multivariable regression. Subsequently, association of HLA-C*05 to its receptor KIR2DS4fl, expressed on natural killer (NK) cells, and differential mortality to historic pandemics were analyzed. HLA-A*

SUBMITTER: Sakuraba A 

PROVIDER: S-EPMC7699862 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature